Welcome to OAE!
The Ontology of Adverse Events (OAE) is a community-driven ontology that is developed to standardize and integrate data on biomedical adverse events (e.g., vaccine and drug adverse events) and support computer-assisted reasoning.
OAE was previously named Adverse Event Ontology (AEO). Due to the name conflict, we changed our ontology name space from AEO to OAE starting from November 16, 2011. In the early version of AEO, an 'adverse event' assumes a causal association between a medical intervention and an adverse event outcome (Reference: see our AEO article presented in AE workshop in 2011). In a late version of AEO and in OAE, we have updated the definition of 'adverse event' to also cover those possible non-causal adverse events. Correspondingly, we have changed our the name 'adverse event' described in the above AEO paper to 'causal adverse event' (Reference: see the PLoS ONE paper). The contents described in the AEO paper still fit in well with the new OAE ontology term 'causal adverse event'. The no-assumption of causal association between a medical intervention (e.g., vaccination, drug administration) and an adverse event is consistent with the concept defined in the Vaccine Adverse Event Reporting System (VAERS) and FDA Adverse Event Reporting System (FAERS). One primary application of the OAE is to use OAE as a platform to model and analyze the causal association.
The OAE development has becoming an international collaboration. Our development group includes experts from academia and industry and covers the adverse events induced by different medical interventions such as administrations of vaccine, drug, medical devices, nutritional products.
More participations are welcome!
Pleasea Cite our Papers:
- Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.
- Sarntivijai S, Xiang Z, Shedden KA, Markel H, Omenn GS, Athey BD, and He Y. Ontology-based combinatorial comparative analysis of adverse events associated with killed and live influenza vaccines. PLoS ONE. 2012, 7(11): e49941. doi:10.1371/journal.pone.0049941.
- He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. AEO: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full length conference proceeding paper. [Check out: Oliver He's AEO presentation in AE workshop, ICBO 2011]
- In the Adverse Event Representation Workshop in ICBO 2011, Oliver He presented the AEO (now OAE) development project.
- In VDOSME 2012 workshop: http://kr-med.org/icbofois2012/vdosme/, Oliver He presented updates on the OAE development and its applications.